A Review of Genes Associated with Obesity Susceptibility: Findings from Association Studies

Obesity is described as the accumulation of excess body fat. Several health issues are caused by fat, including cancer, type 2 diabetes, and cardiovascular disease. Additionally, obesity rates among schoolchildren young adults rising globally, putting people at risk chronic diseases. Genetics, epigenetic modification, epigenomics, environmental factors influence inheritance patterns significantly. This systematic study aimed to classify investigate polymorphisms novel candidate genes. genes have been suggested, includingat mass obesity-associated gene (FTO), leptin (LEP), receptor (LEPR), peroxisome proliferatoractivated gamma (PPARG), melanocortin 4 (MC4R), insulin-induced (INSIG2), proprotein convertase subtilisin/kexin 1 (PCSK1), adrenoceptor beta (ADRB2), uncoupling protein (UCP2). The study’s literature review identified in scientific papers published databases such Web Science, PubMed, Google Scholar, Embase, others over past three decades. There evidence that genetic variations contribute childhood obesity, adolescent adult obesity. Identifying functional differences further defining implicated molecularly physiologically involved andpathways efficient therapeutic approaches fighting. Technological advances recently demonstrated changes mutations can be used biological markers, indicators, targets.